Amgad Gabr
Associate professor of psychiatry, department of Psychiatry, Al-Azhar University, Associate professor, PhD, Psychiatry, Egypt
Mohamed Said
Lecturer of Physical Therapy for Elderly and Cardiovascular/ Respiratory disorders, Department of Physical Therapy for Elderly, National Institute of Longevity Elderly Sciences (NILES), Beni-Suef University, Beni-Suef Egypt, Assistant Professor of Physical Therapy for Cardiovascular/ Respiratory disorders and geriatrics at Department of Physical Therapy, Faculty of Allied medical Sciences, Aqaba University of Technology, Aqaba, Jordan, Associate professor, PhD, Physical Therapy for Cardiovascular/ Respiratory disorders and Geriatrics, Egypt
Shaimaa Maklad
lecturer of physiology, department of physiology, faculty of medicine, Al Azhar University, Lecturer of physiology, PhD, Medical physiology, Egypt
Seham Abdelsadek
Assistant professor of neurology, department of neurology, faculty of medicine for girls, Alazhar University, Assistant professor of neurology, PhD, Neurology, Parkinson disease, Cairo, Egypt
Sahar Ghonem
Lecturer of Neurology, department of Neurology, faculty of medicine, Alazhar University, Lecture of neurology, Bachelor's-Master-MD, Neurology, Cairo, Egypt
Reham Ahmed
Lecturer of Physical Therapy for Neuromuscular Disorders, Faculty of Physical Therapy, Beni-Suef University, Lecturer of physical therapy for Neuromuscular disorders, PhD in Neuromuscular disorders and its surgeries, Physical therapy in Neuromuscular disorders, New Beni-Suef, Egypt
Aisha Abdellateef
Assistant Professor of psychiatry, Psychiatry Department, Faculty of Medicine for Girls, Al-Azhar University, Assistant Professor, PhD, Psychiatry, Cairo, Egypt
Ahmed Khalifa
Lecturer of psychiatry, department of psychiatry, faculty of medicine, AL Azhar university, Lecturer of psychiatry, PhD, Psychiatry, Cairo, Egypt
Marwa Salah- Eldien Abd-Elraouf
Assistant professor of public health, department of public health and community medicine, faculty of medicine, Benha university, Assistant professor, MD, Public health, Benha, Egypt
Amr Shehata
Fellow of Cardiology, Cardiology department, Benha teaching hospital, General organization for teaching hospitals and institutes, Consultant of cardiology, MD, Cardiology, Cairo, Egypt
Mona Hussein
Clinical Pathology department, Faculty of Medicine for Girls, Al-Azhar University, Assistant professor of Clinical Pathology department, Faculty of Medicine for Girls, Al-Azhar University, MD, Clinical pathology, Cairo, Egypt
Taher Abd Elkareem
Assistant Professor of Cardiology Islamic center of Cardiology Al Azhar university, Consultant cardiology in Nizwa hospital, Oman, Assistant Professor of Cardiology, MD Cardiology, Cardiology, Egypt
Abdelaal Alkhouly
Lecturer of cardiology, Islamic cardiac center, Alazhar University, Lecturer of cardiology, PhD, Cardiology, Cairo, Egypt
Shimaa Hikal
Lecturer of cardiology, Islamic cardiac center, Alazhar University, Lecturer of cardiology, PhD, Cardiology, Cairo, Egypt
Marwa Mohiy Eldin
Internal medicine department, Benha faculty of medicine, Lecturer, MD Cardiology, Cairo, Egypt
Ahmed Abd-Elrhman
Lecturer of physiology, department of physiology, faculty of medicine, Alazhr university, Lecturer, Physiology, Assuit, Egypt
Suzan Elshishtawy
Lecturer of clinical pathology, department of clinical pathology, faculty of medicine, Ain Shams university, Lecturer, PhD, Clinical pathology, Cairo, Egypt
Noha O.Shawk
lecturer of physiology, department of physiology, faculty of medicine, Helwan University, Lecturer of physiology, MD, Medical physiology, Egypt
Wael A. Khattab
lecturere of medical physiology, department of medical physiology, faculty of medicine, Al-Azhar University, lecturere of Medical physiology, MD, Medical physiology, Egypt
Albayoumi AB Fouda
Ass.prof. of medical physiology, department of medical physiology, faculty of medicine, Al-Azhar University, Ass.prof. of Medical physiology, MD, Medical physiology, Egypt
Mohammad O. Zarad
Lecturer of medical physiology, Faculty of medicine, Al Azhar university, Lecturer of medical physiology, MD, Medical physiology, Egypt
Passant Hewady
Lecturer of physiology, faculty of medicine Tanta university, Lecturer of physiology, PhD, Physiology, Tanta, Egypt
Abstract
Background:Parkinson's disease (PD) is a progressive neurological disorder marked by the degeneration of neurons that produce dopamine in the substantia nigra area. This results in symptoms such as tremors, rigidity, bradykinesia, and difficulty maintaining balance. These symptoms significantly affect the individual's quality of life.
Aim of the work: We aimed to assess the functional impact of aerobic exercise on cardiovascular autonomic function, peripheral neuropathy (gait and balance), depression, and quality of life in Parkinson’s disease. Patients and Methods: The current investigation is a two-arm parallelrandomised controlled trial. The sample was chosen using a non-probabilistic method. A random 1:1 ratio was used to assign the candidates to one of the 2 groups:25 case in the exercise interventions group and 25 case as control group (no invasive intervention). Result: As regard motor “Nerve conduction study” of popliteal and Tibialis nerve at both lower limbs, Na+/I− symporter (NIS L) score, “Brain-derived neurotrophic factor” (BDNF) , quality of life score , “Beck Depression Inventory” (BDI) score there was insignificant differences between two groups at baseline however, after six weeks, a marked improvement was noted in interventional group vs control.
Conclusion: It was found that aerobic activity could lead to enhancements in motor NCV in popliteal fossa, and Tibial nerve, sural sensory nerve NCV, TINETTI gait and balance test, clinical neuropathy score, NIS L score, BDNF, quality of life score, BDI score.
