Assessment of storage containers effect on stability of cannabis metabolites in urine using Liquid Chromatography-Tandem Mass Spectrophotometry technique

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Published: Oct 9, 2024
Keywords:
Cannabis, Stability, containers, storage, LCMSMS, THC-COOH.

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Idris Mohammed
Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
Eiman Awadh Abdullah
Department of Medical Laboratory Science, College of Health Sciences, University of Sharjah, Emirates of Sharjah, United Arab Emirates.
Aisha Al-Shehi
Forensic Toxicology Section, Sharjah Police Forensic Science Laboratory, Emirates of Sharjah, United Arab Emirates.
Mussab Osama
Department of Chemistry, College of Sciences, University of Sharjah, Emirates of Sharjah, United Arab Emirates.
Gavash Harsha Kannikant
Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.

Abstract

∆9-Tetrahydrocannabinol (∆9 -THC) metabolites such as THC-OH (11-Hydroxy-Δ9-tetrahydrocannabinol), THC-COOH (11-Nor-9-carboxy-Δ⁹-tetrahydrocannabinol) and THC-COOH-glucuronide (11-Nor-9-carboxy-Δ⁹-tetrahydrocannabinol conjugate) were studied in urine samples for their stability with respect to different storage conditions involving containers, temperature and time using validated liquid chromatography – tandem mass spectrometry method. It was concluded that storing the samples for less than three months either at 4 ºC or -20ºC in the silanized clear or amber glass was desirable. 

Article Details

Issue
Vol. 27 No. 4 (2024)
Section
Articles
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