Effect of Hypervitaminosis D on Histological Structure of Liverin Albino Rats

Abstract

Vitamin D is essential for overall health, wellbeing, andincreased mortality and a variety of adverse consequences have been caused by hyper vitamin D insufficiency. This study was designed to determine the effects of toxic doses of vitamin D on the structures of liver and calcification in rats due to hypervitaminosis D. Forty adult Wistar rat males were divided to four groups at random and administered both oral gavage of vitamin D excepted control group water. For a period of sixty days, the 10 rats in the control group received distilled deionized water every day. Three of the experimental groups received varying doses of vitamin DI.U. per day for 60 days: a low dose (the LD, 10 rats) (3000 IU/rat/day), intermediate dose (ID, 10rats/8000 IU/rat/day, and high dose (HD, 10 rats, 20000 IU/rat/day). The LD group's organ histopathology exhibited fewer changes but the ID and HD groups' liver showed more deeply restricted degenerative deviations. In conclusion, the histological structure of liver calcification were affected with increased vitamin D dosage' with appeared of calcification.